Custom Peptides
Cayman Chemical CotadutIdeacetate 10mg
A synthetic peptide and peptide dual agonist of GLP-1R and GCGR; increases cAMP accumulation in CHO cells overexpressing recombinant human GLP-1R or GCGR (EC50s = 6.9 and 10.2 pM, respectively); reduces food intake and fat mass, as well as improves glucose tolerance in DIO mice at 10 nmol/kg; reduces food intake and body weight in wild-type, but not Glp1r knockout mice; reduces the hepatic lipid percentage in both wild-type and Glp1r knockout mice; reduces total hepatic triglycerides, diglycerides, cholesterol, and free fatty acids, as well as reduces hepatic inflammation and fibrosis, in an ob/ob mouse model of NASH induced by a high-trans fat, high-fructose, and high-cholesterol diet at 10 nmol/kg
Cayman Chemical 1 5-DIcaffeoylquInIc AcId 10mg
An HIV-1 integrase inhibitor and free radical scavenger; inhibits HIV-1 integrase 3' end processing, end joining, and disintegration (IC50s = 0.35, 0.56, and 0.84 μg/ml, respectively); inhibits HIV-1 replication in MT-2 cells (ED50 = 2 μg/ml); dose-dependently reduces the level of free radicals released by FMLP stimulation of PMN cells at 0.25-1 μM; dose-dependently increases cell survival and GSH levels and decreases ROS and LDH release when rat cerebral astrocytes in an oxygen-glucose deprivation/reperfusion assay using rat cerebral astrocytes at 5-100 μM
Cayman Chemical 1 3DIpalmItoleoyl GlycRol 10mg
A diacylglycerol with palmitoleic acid at the sn-1 and sn-3 positions; selectively inhibits α-glucosidase from S. cerevisiae over rat enzyme (IC50s = 4.45 and 9,326.5 μM, respectively); has been used in the formation of lipid bilayers to study the effects of membrane composition and valinomycin on membrane potential
Cayman Chemical DIquat-d12bromIde 10mg
An internal standard for the quantification of diquat by GC- or LC-MS
Cayman Chemical 13methyl PentadecnoIc ACD 10mg
A methylated fatty acid methyl ester; has been found in the bioactive fraction of A. malabarica extract, C. variabilis microalgae, and baboon liver
Cayman Chemical BzNleKRRAMChydrochlorIde 10mg
A fluorogenic substrate for YFV NS3 or DV NS2B/3 serine proteases; AMC is released upon enzymatic cleavage by YFV NS3 or DV NS2B/3 serine proteases and its fluorescence can be used to quantify YFV NS3 or DV NS2B/3 serine protease activity; ex/em = 340-360/440-460 nm, respectively
Cayman Chemical MeOSucRPYpNAtrIfluoroace 10mg
A colorimetric serine protease substrate; cleavage of the RPY peptide sequence releases pNA, which can be quantified by colorimetric detection at 405 nm as a measure of serine protease activity
Cayman Chemical N3hydroxybutyrylLHomoserI 10mg
An N-acyl-homoserine lactone produced by the bacterium V. splendidus; has been found in sequencing batch biofilm reactors used in wastewater treatment; racemic version of the V. harveyi autoinducer N-((R)-3-hydroxybutanoyl)-L-homoserine lactone
Cayman Chemical JatrorrhIzInchlorIde 10mg
An alkaloid with diverse biological activities; active against P. falciparum (IC50s = 422 and 1,607 ng/ml for D-6 and W-2 clones, respectively) and E. histolytica (IC50 = 82.7 μM); inhibits the growth of C8161 human melanoma cells in vitro (IC50 = 47.4 μM); inhibits C8161 cell-mediated neovascularization in a Matrigel™ plug assay in mice at 50 μg/animal; reduces serum levels of triglycerides, LDL-C, AST, and ALT in a high-fat diet-induced mouse model of hyperlipidemia at 20 and 100 mg/kg; a metabolite of berberine
Cayman Chemical 1 2DIbutyryl3PalmItoylrac 10mg
A triacylglycerol; has been found in butterfat and maternal Dufour's glands of Anthophora bees
Cayman Chemical PunIcalagIn 10mg
An ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects; prevents accumulation of cardiac triglyceride and cholesterol via AMPK-mediated modulation of mitochondria and phase II enzymes
Cayman Chemical 2-AIhydrochlorIde 10mg
An aminoindane that serves as the starting point for the synthesis of psychoactive compounds, such as 5,6-methylenedioxy-2-aminoindane; has modest analgesic and stimulatory properties; intended for forensic applications
Cayman Chemical SynthetIc Aurapten 10mg
A coumarin derived from citrus plants with anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities; inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis